The present invention concerns a for preparing 5 [ACETYL (2,3 -DIHIDROXIPROPIL) AMINO] -N, N'-bis (2, 3-dihydroxypropyl) -2,4,6-triiodo-1,3 PROCESS -BENCENODICARBOXAMIDA represented by formula (I) FROM 5-amino-1,3-benzenedicarboxylic acid of formula (II). Said process comprising the steps: (a) REACTION IN PHASE BETWEEN Heterogeneous 5-amino-2,4,6-1,3-benzenedicarboxylic -TRIIODO and thionylchloride in a solvent selected from the group consisting of: HYDROCARBONS (C7-16) branched or straight chain, AROMATIC HYDROCARBONS (C7-8), 1,1,1-trichloroethane, n-butyl acetate, diglyme (diethylene glycol, dimethyl ether) in the presence of catalytic AMOUNTS OF A tERTIARY aMINE, to obtain a compound of formula (III); (B) acetylation reaction of said compound of formula (III) with glacial acetic acid, which acts both as a solvent and as reagent and THIONYL CHLORIDE; (C) forming a compound of formula (V) by reacting the compound of formula (IV) containing 1-amino -2.3 propanediol, by reacting the compound (IV) in a solvent selected from dipolar aprotic GROUP dimethylformamide (DMF), dimethylacetamide (DMA), dimethylsulfoxide (DMSO) ON -Methyl -pyrrolidine; (D) Alkylation OF SUCH COMPOUND (V) AQUEOUS SOLUTION TO A basic pH by addition of a mixture of calcium hydroxide and sodium hydroxide, WITH 3-chloro-propanediol or epichlorohydrin -1.2, and a temperature BETWEEN 40 AND 90 ° C.
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