GAMMA EMITTING, CCK-A ANTAGONISTS FOR PANCREATIC IMAGING

摘要

Novel radiolabeled cholecystokinin-A (CCK-A)antagonists have been developed having the general structureformula I:(see above formula)which, after intravenous injection, localize in the pancreasas a result of specific binding to CCK-A receptors. Thesetracers, when labeled with appropriate radiohalogens, areuseful as commercial diagnostic imaging radiopharmaceuticalsand radiotherapeutic drugs.