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METHOD OF MAKING POLYHYDRIC ALCOHOL SOLUTIONS OF ENHANCED EFFICACY ANTIPERSPIRANT ACTIVES
METHOD OF MAKING POLYHYDRIC ALCOHOL SOLUTIONS OF ENHANCED EFFICACY ANTIPERSPIRANT ACTIVES
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机译:制备高效抗精神病药活性成分的多元醇溶液的方法
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摘要
The present invention comprises a process of preparing a solution of anenhanced efficacy aluminum antiperspirant salt in a polyhydric alcohol by (a)providing an aqueous solution consisting essentially of about 5 % to about 18% by weight of an enhanced efficacy aluminum antiperspirant salt in water, theenhanced efficacy aluminum antiperspirant salt having been prepared in situwithout having been dried to a solid powder; (b) mixing the aqueous solutionwith a sufficient amount of a liquid polyhydric alcohol to provide a mixedsolution which has an antiperspirant salt to polyhydric alcohol ratio of about1:4 to about 1.2:1; and (c) rapidly evaporating the water from the mixedsolution under vacuum to provide a final liquid polyhydric alcohol solutioncontaining about 20 to 50 % enhanced efficacy aluminum antiperspirant salt andabout 2 to 16 % water, with the balance being polyhydric alcohol. An alkalineglycinate salt, such as sodium, potassium or zinc glycinate, may be added tothe polyhydric alcohol prior to the addition of the antiperspirant saltsolution in order to raise the pH of the recovered product to about 4.1 to 5Ø
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