INTERLEUKIN-1 RECEPTOR-ASSOCIATED PROTEIN KINASE AND ASSAYS

摘要

The invention relates to human Interleukin-1 Receptor-Associated ProteinKinases (IRAKs), nucleic acids which encode IRAKs and hybridization probes andprimers capable of hybridizing with IRAK genes and methods of using thesubject compositions; in particular, methods such as IRAK-based in vitrobinding assays and phosphorylation assays for screening chemical libraries forlead compounds for pharmacological agents.