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PRODUCTION PROCESS FOR POLYMERIC MICELLE CHARGED THEREIN WITH DRUG AND POLYMERIC MICELLE COMPOSITION
PRODUCTION PROCESS FOR POLYMERIC MICELLE CHARGED THEREIN WITH DRUG AND POLYMERIC MICELLE COMPOSITION
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机译:药物和聚合物胶束组成的聚合物胶束的制备工艺
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摘要
Provided are a production process for a polymeric micelle which is stable and has a high drug content and a composition con- taining such polymeric micelle. Disclosed are a production process for a polymeric micelle, comprising the steps of dissolving a drug and a specific copolymer in a water non-miscible organic solvent to pre- pare a solution, mixing the resulting solution with water to form an O/W type emulsion and then slowly volatilizing the organic solvent from the solution, and a polymeric micelle composition charged therein with a water-scarcely soluble drug, which can be obtained by the above production process.
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