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NOVEL RECOMBINANT ANTIBODY, AMINO ACID SEQUENCES OF ITS COMPLEMENTARITY DETERMINING REGIONS AND GENES ENCODING THE SAME
NOVEL RECOMBINANT ANTIBODY, AMINO ACID SEQUENCES OF ITS COMPLEMENTARITY DETERMINING REGIONS AND GENES ENCODING THE SAME
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机译:新型抗体,互补决定区的氨基酸序列和编码相同序列的基因
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摘要
An H chain polypeptide or its fragment of a recombinant antibody against humanTNF.alpha. having at least one of the following amino acid sequences: a) asCDR-H1 Gly-Tyr-Thr-Phe-Thr-Asn-Tyr-Gly-Met-Asn; b) as CDR-H2 Trp-Ile-Asn-Thr-Tyr-Thr-Gly-Glu-Pro-Thr-Tyr-Ala-Asp- Asp-Phe-Lys-Gly; and c) as CDR-H3 Tyr-Asp-Tyr-Asp-Gly-Phe-Asp-Tyr; an L chain polypeptide of a recombinant antibodyagainst human TNFa having at least one of the following amino acid sequences:a') as CDR-L1 Thr-Ala-Ser-Ser-Ser-Val-Ser-Phe-Ser-Tyr-Leu-His; b') as CDR-L2Tyr-Ser-Thr-Ser-Asn-Leu-Ala-Ser; and c') as CDR-L3 His-Gln-Tyr-Leu-Arg-Ser-Pro-Tyr-Thr; and humanized antibodies against human TNF.alpha. or fragmentsthereof which comprise the above-described H chain polypeptide or its fragmentand the above-described L chain polypeptide. Also, a process for producing ahumanized anti-TNF.alpha. antibody by transforming host cells with anexpression vector having a gene encoding the above antibody, etc. is disclosed.
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