Fusion protein, complementarity determining region, nucleic acid molecule and sequence thereof, antibody, process its preparation and investigation, pharmaceutical composition, recombinant plasmid, host cell and diagnosis method

摘要

In the present invention, there are described a fusion protein having binding specificity for human interleukin-4(IL4), an immunoglobulin light or heavy chain complementarity determining region (CDR), a nucleic acid molecule encoding CDR, a humanized and chimeric antibody comprising a heavy chain and a light chain, a pharmaceutical composition comprising the fusion protein, an isolated nucleic acid sequence, a recombinant plasmid comprising the nucleic acid sequence, a host cell transfected with the recombinant plasmid, a process for preparing the a humanized antibodies specific for human interleukin-4, a method for diagnosing allergies and other conditions associated with excess immunoglobulin E production in a human and a method for screening monoclonal antibodies which have a high titer for human IL4.