MIXED STRUCTURES RESULTING FROM THE INCORPORATION OF A BIOLOGICAL MACROMOLECULE, PARTICULARLY DNA, INTO A LIQUID-CRYSTAL PHASE OF AMPHIPHILES, AND VESICLES OBTAINED FROM THESE STRUCTURES

摘要

The invention relates to a structured mixed phase that results from theincorporation of a biological macromolecule into a liquid-crystal, preferablylamellar, amphiphile phase, characterised in that the proportion of saidbiological macromolecule in said structured mixed phase is at least 5 wt. % inrelation to the amphiphile compounds making up the liquid-crystal amphiphilephase and in that at least one of the two entities constituted by thebiological macromolecule and the group of amphiphile compounds has no charge.The biological macromolecules incorporated in the inventive structured mixedphases are preferably chosen from the polynucleotides, particularly DNA orRNA, proteins and polysaccharides. The invention also relates to vesiclesobtained by dispersing the structured mixed phases above.