ANDROGEN RECEPTOR SUPPRESSORS IN THE THERAPY AND DIAGNOSIS OF PROSTATE CANCER, ALOPECIA AND OTHER HYPER-ANDROGENIC SYNDROMES

摘要

Substituted phenylalanines are provided comprising an hydantoin, urea or 2- hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as well as radiolabeled derivatives thereof. The compounds bind specifically to the androgen receptor and find u se in indications associated with the androgen receptor, such as cell hyperplas ia dependent on androgens, hirsutism, acne and androgenetic alopecia.