3D STRUCTURE OF POLYPEPTIDES CONTAINING A TPR-STRUCTURE MOTIF WITH CHAPERONE-BINDING FUNCTION, CRYSTALS THEREOF AND COMPOUNDS FOR INHIBITION OF SAID PEPTIDES

摘要

The invention relates to 3-D structures of a polypeptide, whereby, in the 3-Dstructure, the polypeptide contains at least one amino acid sequence of a TPR-structure motif from a Hop protein, or a derivative thereof. The inventionfurther relates to crystals, comprising at least one polypeptide in theirasymmetric unit and, optionally, at least one further compound, whereby thepolypeptide adopts the above 3D-structure in the crystal. Furthermore, methodsfor the production of such crystals and compounds, having the property ofbinding, as ligands, to structural regions of a Hop protein are disclosed.Additionally, a method for the identification of inhibitors is disclosed,whereby ligands with inhibitor functions for the interaction of a Hop proteinwith at least one chaperone protein are obtained. Such inhibitors are usefulfor the treatment of tumour disease states, immunosupression, GVDH, or thetreatment of viral infections.