System and method for extended delivery of a therapeutic agent with its receptorloading dose

摘要

The present invention provides systems and methods for administering a therapeutic agent to a patient in need an initial loading dose of the therapeutic agent administered in conjunction with a long-term maintenance dose of the therapeutic agent. The present invention discloses subcutaneous-implantable dosage forms capable of administering the long-term maintenance dose of the therapeutic agent in a steady state or zero order manner. Systems and methods for administering an initial loading dose of a therapeutic agent administered in conjunction with an extended release dosage form of the therapeutic agent, and optionally in conjunction with a receptor loading dose of the therapeutic agent, are useful in the treatment of various diseases and disorders.