Anti-Alpha 8 Integrin Immunoliposomes: A Novel System for Delivery of Therapeutic Agents to the Renal Glomerulus in Systemic Lupus Erythematosus

摘要

ObjectiveGlomerular mesangial cells are active participants in pathogenesis of lupus glomerulonephritis (GN). Thus, targeted delivery of therapeutics to mesangial cells would be an attractive approach to treatment. However, lack of unique mesangial cell surface markers has hampered this process. The objective of this study was to identify mesangial marker(s) and develop a system for targeted drug delivery to the glomerulus.