Improvements in or relating to diagnosis or prediction of headache

摘要

Disclosed is a method of predicting the onset of a period of maximum probability of occurrence of headache (other than a cluster headache) in a human subject, the method comprising the steps of: a) making a first measurement of the concentration of one or more analytes in a sample of urine from the subject at one or more time points to establish a reference value for the analyte concentration; and b) making a second measurement of the concentration of said analyte(s) in a sample of urine from the subject at one or more later time points; wherein the concentration of said analyte undergoes a characteristic change relative to the reference value, detection of said characteristic change being indicative of the onset of the period of maximum probability of occurrence of headache in the subject.