Fyn kinase as a target for modulation of integrin mediated signal transduction

摘要

The present invention describes a direct interaction between phosphorylated GPIIIa cytoplasmic domains with 1) isrc//inon-isrc/i family kinases and 2) phosphatases. The invention provides methods for identifying agents that block GPIIIa interactions with isrc//inon-iscr/i family kinases and phosphatases, methods of using agents that block GPIIIa interactions with isrc//inon-isrc/i family kinases and PIP-1C phosphatases to modulate biological and pathological processes and agents that block GPIIIa mediated binding to isrc//inon-iscr/i family kinases and PIP-1C phosphatases, thereby modulating related GPIIIa mediated signaling.