Controlled release of therapeutics by in-situ entrapment by matrix cross-linking

摘要

The present invention is directed to pharmaceutical compositions, and method for preparing pharmaceutical compositions, comprising a cross-linked matrix physically entrapping at least one therapeutic agent. The matrix is prepared by incubating a solution comprising the at least one therapeutic agent and at least one polymer on which at least two thiol groups are present under conditions that cause cross-linking of the thiol groups to form a matrix entrapping the at least one therapeutic agent. The matrix comprising the at least one therapeutic agent has at least one controlled release in-vivo kinetic profile, and may have additional profiles for the same agent. The matrix may also comprise more than one therapeutic agent, and each additional therapeutic agent may have one or more controlled release in-vivo kinetic profile.