Therapy, prevention of recurrence, and diagnosis of colorectal cancer with radiopharmaceuticals

摘要

Methods and composition for therapy, prevention of recurrence, and diagnosis of colorectal cancer with radiopharmaceuticals. A prodrug is administered of a desired active cytotoxic pharmaceutical, specifically a radiopharmaceutical. The prodrug is converted to the active pharmaceutical at the desired site of the malignancy or potential malignancy. For example, glycoside derivative prodrugs of 5-[125]iodo-2'-deoxyuridine are converted to the desired active form in the lumen of the intestine by the glycosidases produced by intestinal bacterial flora.