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Molecular determinants of tropism and virulence in enteroviruses
Molecular determinants of tropism and virulence in enteroviruses
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机译:肠病毒的嗜性和毒力的分子决定因素
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摘要
Recombinant enteroviruses for use as vaccines or vectors, which are modified in tropism or virulence, are disclosed. Also disclosed are DNA constructs comprising enterovirus-derived molecular determinants of tropism or virulence for use in targeting genes of interest to specific cells or tissues. The recombinant enteroviruses and DNA constructs comprise molecular determinants of tropism and virulence localized in specific domains of the 5'NTR of the enteroviral genome.
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