GP120 polypeptides having conformational discontinuous chemokine receptor binding sites and methods of inhibiting HIV infection

摘要

A gp120 conformational binding site that is formed by the binding of gp120 and CD4 which permits binding of the complex to the chemokine receptors is disclosed. Binding assays which permit the ready screening for molecules which affect the binding of gp120 and the chemokine are taught as well as specific targets for affecting the binding.