Phosphonated agents and their antiangiogenic and antitumorigenic use

摘要

The present invention relates to novel phosphonic acid substituted agents and their pharmaceutical compositions. The novel agents are defined by the following formula: (P-Yn1)m1-Q-K-(Q2-(Yn2-P)m2)j wherein Y is -OCO-, NR1CO- or CON(R1)R2-; Q1 and Q2 are substituted or unsubstituted aryl groups; K is H, -NHCONH-, NHCS-NH, -NHCO-R3- or -NHCSR3-CSNH-; provided when K is H, j is 0; j is 0, 1, 2; n1 and n2 are independently 0, 1 or 2; and m1 and m2 are independently an integer from 1-4.