CELLS WITH ENFORCED EXPRESSION OF BCL-XL

摘要

The present invention relates to genetically modified CD34+ hematopoietic cells which overexpress a BCL-XL protein, cell populations comprising such cells and their medical uses. The present invention also relates to methods of enforced BCL-XL expression in hematopoietic cells. Such enforced expression results in an increase in hematopoietic cell viability, expansion, and engraftment ability.