ANTISENSE OLIGONUCLEOTIDE MODULATING CYCLIN E GENE EXPRESSION AND THERAPEUTIC USES THEREOF

摘要

The present invention relates to antisense oligonucleotides directed to the human cyclin E gene for inhibiting its expression, and to a method for inhibiting cellular proliferation. The antisense oligonucleotides of the present invention have been designed from the 5' and 3'-untranslated region of the cyclin E gene for inhibiting the expression of the cylcing E gene. These antisense oligonucleotides can be used for research purposes, diagnostics and treatment of disease. Methods for specifically modulating cyclin E expression in cells and tissues using the antisense oligonucleotides are disclosed. Methods for diagnosis, detection and treatment of pathologies involving cyclin E gene are disclosed.