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COMPOSITIONS AN INHIBITOR OF AN ACCRAB-LIKE EFFLUX PUMP FOR REDUCUNG MICROBIAL RESISTANCE TO DRUGS
COMPOSITIONS AN INHIBITOR OF AN ACCRAB-LIKE EFFLUX PUMP FOR REDUCUNG MICROBIAL RESISTANCE TO DRUGS
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机译:组成一种类似ACCRAB的外排泵的抑制剂,用于降低药物的耐药性
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摘要
The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of screening for inhibitors of AcrAB-like efflux pumps, and methods of enhancing antimicrobial activity of drugs are provided. Pharmaceutical composition comprising an inhibitor of an AcrAB-like efflux pump and an antimicrobial agent are also provided.
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