BILIRUBIN OR BILIVERDIN DEGRADATION FRAGMENTS

摘要

A pharmaceutical composition comprising a compound of formula (I) wherein X is an electron withdrawing group, Y1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, -SO¿2?R?4, -CO¿2R4, -CONHR4 or -COR4, and each of R?1, R2 and R4¿, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, or a compound of formula (II) wherein each of Y?2 and Y3¿, which may be the same or different, is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, -SO¿2?R?9, -CO¿2R9, -CONHR9 or -COR9, Z is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclyl, -CH=C(NHR10)CH((CH¿2?)mCO2R?11¿)(C=O)CH¿3? or -CH2(C=O)CH((CH2)mCO2R?11¿)(C=O)CH¿3, R?8 is -(CH¿2?)nCO2R?12¿, each of R?5 to R7 and R9 to R12¿, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, and each of m and n, which may be the same or different, is 1 to 6 or a compound of formula (III) wherein each of Y4 to Y6, which may be the same or different, is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, -SO¿2?R?19, -CO¿2R19, -CONHR19 or -COR19, each of R?16 and R17¿, which may be the same or different, is -(CH¿2?)pCO2R?20¿, each of R?13 TO R15 and R18 to R20¿, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, and p is 1 to 6, or other photolabile degradation product of bilirubin or biliverdin or derivative of a photolabile degradation fragment of bilirubin or biliverdin, or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier or diluent.