BILIRUBIN OR BILIVERDIN DEGRADATION FRAGMENTS

摘要

A pharmaceutical composition comprising a compound of formula (I) wherein X is an electron withdrawing group, YSUP1 /SUPis hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, -SOSUB2/SUBRSUP4/SUP, -COSUB2/SUBRSUP4/SUP, -CONHRSUP4 /SUPor -CORSUP4/SUP, and each of RSUP1/SUP, RSUP2 /SUPand RSUP4/SUP, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, or a compound of formula (II) wherein each of YSUP2 /SUPand YSUP3/SUP, which may be the same or different, is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, -SOSUB2/SUBRSUP9/SUP, -COSUB2/SUBRSUP9/SUP, -CONHRSUP9 /SUPor -CORSUP9/SUP, Z is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclyl, -CH-C(NHRSUP10/SUP)CH((CHSUB2/SUB)SUBm/SUBCOSUB2/SUBRSUP11/SUP)(C-O)CHSUB3 /SUBor -CHSUB2/SUB(C-O)CH((CHSUB2/SUB)SUBm/SUBCOSUB2/SUBRSUP11/SUP)(C-O)CHSUB3/SUB, RSUP8 /SUPis -(CHSUB2/SUB)SUBn/SUBCOSUB2/SUBRSUP12/SUP, each of RSUP5 /SUPto RSUP7 /SUPand RSUP9 /SUPto RSUP12/SUP, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, and each of m and n, which may be the same or different, is 1 to 6 or a compound of formula (III) wherein each of YSUP4 /SUPto YSUP6/SUP, which may be the same or different, is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, -SOSUB2/SUBRSUP19/SUP, -COSUB2/SUBRSUP19/SUP, -CONHRSUP19 /SUPor -CORSUP19/SUP, each of RSUP16 /SUPand RSUP17/SUP, which may be the same or different, is -(CHSUB2/SUB)SUBp/SUBCOSUB2/SUBRSUP20/SUP, each of RSUP13 /SUPTO RSUP15 /SUPand RSUP18 /SUPto RSUP20/SUP, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, and p is 1 to 6, or other photolabile degradation product of bilirubin or biliverdin or derivative of a photolabile degradation fragment of bilirubin or biliverdin, or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier or diluent