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PLATELET AGGREGATION INHIBITORY PEPTIDES

机译:血小板凝集抑制肽

摘要

The present invention provides compounds or salts thereof, that are represented by the general formula (I): Pro-Ser-A-B-Asp-C-D, wherein A is an amino acid other than amino acids having a guanidino group at a side chain, B is an amino acid, C is an amino acid having a hydrophobic group at a side chain and D is a hydroxy or an amino group. The compounds and salts thereof of the present invention are useful since they have excellent platelet aggregation-inhibiting and blood coagulation-inhibiting activities and are highly safe.
机译:本发明提供由通式(I)表示的化合物或其盐:Pro-Ser-AB-Asp-CD,其中A是除在侧链具有胍基的氨基酸以外的氨基酸,B C为氨基酸,C为在侧链具有疏水基的氨基酸,D为羟基或氨基。本发明的化合物及其盐具有优异的抑制血小板凝集和抑制凝血的活性,并且是高度安全的,因此是有用的。

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