BENZOXAZINE DERIVATIVES AND BENZOTHIAZINE DERIVATIVES HAVING NOS-INHIBITORY AND ANTIOXIDANT PROPERTIES

摘要

The invention relates to compounds of formula (I) and to the tautomeric and isomeric forms and salts thereof, wherein: X represents O or S; R1 represents -(CHR9)n-NR7-A-NR8-B, -(CHR9)n-NR8-B or -(CHR9)n-B; R2 represents hydrogen or R?1 and R2¿, together with two adjacent carbon atoms, form a 5-, 6-, 7- or 8-member ring, which is monocyclic or bicyclic, saturated or unsaturated, and in which 1 or 2 CH¿2? groups can be replaced by oxygen or carbonyl, and which is substituted by -(CHR?9)¿r-NR7-A-NR8-B, -(CHR9)n-B or -(CHR9)r-NR8-B; R3 represents hydrogen or NR?15R16; R4¿ represents hydrogen or acyl; R?5 and R6¿, independent of one another, represent hydrogen, C¿3-7? cycloalkyl, phenyl, C1-6 alkyl, C2-6 alkenyl radicals or C2-6 alkynyl radicals, which can each be substituted by halogen, OH, O-C1-6 alkyl, SH, S-C1-6 alkyl, NR?15R16¿, 5- or 6-member heteroaryl with 1-3 N, O or S atoms, phenyl or C¿3-7? cycloalkyl; A represents a straight-chain or branched C1-6 alkylene or -(CH2)p-Q-(CH2)q-, and; B represents (II) or (III). The invention also relates to the method for preparing said compounds and to their use in medicaments.