PREVENTIVES OR REMEDIES FOR DISEASES IN ASSOCIATION WITH VASCULAR FUNCTIONAL ANOMALY RELATING TO INSULIN RESISTANCE

摘要

It is an object of the present invention to provide a pharmaceutical composition for effectively preventing or improving diseases having vascular dysfunction associated with insulin resistance. The present invention provides pharmaceutical compositions for preventing or treating diseases having vascular dysfunction associated with insulin resistance, comprising as an active ingredient a compound of the formula (I): CHEM wherein R1 and R2 each represents a hydrogen atom or taken together with each other represent a single bond, while R3 represents -CH(OH)CH(OH)CH3, -CH(OCOCH3)CH(OCOCH3)CH3, -CH3, -CH2OH or a phenyl group when R1 and R2 each represents a hydrogen atom, or -COCH(OH)CH3 when R1 and R2 together represents a single bond, or a pharmaceutically acceptable salt thereof.