Polypeptide (scFv) for the detection and removal of CA19-9 antigen positive cells

摘要

Polypeptide (I), comprising an oligopeptide (OP1) having the variable region of the heavy chain (VH) of an anti-CA19-9 antibody (Ab), or its fragment with the same binding specificity for CA19-9 antigen, and an oligopeptide (OP2) based on the variable light chain (VL) region of an Ab, or its fragment, is new. OP1 and OP2 are linked, directly or through a linker peptide (LP). Independent claims are also included for the following: (1) DNA (II) that encodes (I); (2) a vector containing (II); (3) a host organism transformed with the vector of (2); (4) preparation of (I) by culturing cells of (3); (5) radiolabeled forms (Ia) of (I); (6) producing (Ia); and (7) pharmaceutical and diagnostic agents containing (I) and/or (Ia).