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Detection of Alzheimer's disease from cerebrospinal fluid using an immunoassay method
Detection of Alzheimer's disease from cerebrospinal fluid using an immunoassay method
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机译:使用免疫测定法从脑脊液中检测阿尔茨海默氏病
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摘要
The present invention relates to a novel method for the diagnosis of Alzheimer's disease using cerebrospinal fluid.;More particularly, this method consists in contacting a sample of cerebrospinal fluid which contains a glutamine synthetase, having an apparent MT of about 42 000 daltons, with a labeled antibody specific for said glutamine synthetase under conditions that allow the formation of glutamine synthetase-antibody complex formation ; detecting the presence of said glutamine synthetase-antibody complexes ; and correlating the presence of said complexes with the presence of Alzheimer's disease.
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机译:本发明涉及一种使用脑脊液诊断阿尔茨海默氏病的新方法。更具体地讲,该方法在于使含有谷氨酰胺合成酶的脑脊液样品与具有明显M T Sub>的谷氨酸接触约42000道尔顿,具有在允许形成谷氨酰胺合成酶-抗体复合物的条件下对所述谷氨酰胺合成酶具有特异性的标记抗体;检测所述谷氨酰胺合成酶-抗体复合物的存在;并将所述复合物的存在与阿尔茨海默氏病的存在相关联。
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