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PROMOTION OF SELF-RENEWAL AND IMPROVED GENE TRANSDUCTION OF HEMATOPOIETIC STEM CELLS BY HISTONE DEACETYLASE INHIBITORS
PROMOTION OF SELF-RENEWAL AND IMPROVED GENE TRANSDUCTION OF HEMATOPOIETIC STEM CELLS BY HISTONE DEACETYLASE INHIBITORS
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机译:组蛋白去乙酰化酶抑制剂促进造血干细胞自我更新和基因转导的改善
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摘要
A method of promoting stem cell self-renewal is disclosed which comprises exposing a population of stem cells, particularly hematopoietic stem cells, to an effective dose of a histone deacetylase inhibitor, particularly trichostatin A, trapoxin, or chlamydocin. The invention is also directed to the use of histone deacetylase inhibitors to increase the number of transduced stem cells.
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