CINCHONA ALKALOID CATALYST FOR HETEROGENEOUS ASYMMETRIC AMINOHYDROXYLATION OF OLEFINS

摘要

PURPOSE: A process for preparing an optical active aminoalcohol compound using a cinchona alkaloid catalyst having excellent catalytic performance, reusable and excellent in thermal, mechanical stability, a nitrogen source and a base is provided which carries out the heterogeneous asymmetric aminohydroxylation of olefins economically and can improve processing difficulties by high toxicity and volatility of OsO4. CONSTITUTION: In the process for manufacturing an optical active aminoalcohol compound by heterogeneous asymmetric aminohydroxylation of olefins, the process uses a catalytic system containing conventional cinchona alkaloids of formula 1 and a nitrogen source and a base. In formula, Y is hydroquinidinyl represented by formula 2 or hydroquinidinyl represented by formula 3, X represents an unsaturated compound containing 0 or 4 carbons, pyridazine in case X is 0 and phthalazine in case X is an unsaturated compound, R represents methoxy, ethoxy or methyl.