CINCHONA ALKALOID CATALYSTS FOR HETEROGENEOUS ASYMMETRIC AMINOHYDROXYLATION OF OLEFINS

摘要

The present invention relates to method, using a catalyst system comprising a new nose or alkaloid derivative represented by the general formula (I) of known and a nitrogen source and a base in the production process of optically active aminoalcohol compound according to the non-homogeneous asymmetric amino-hydroxy reaction of the olefin compound It relates to a process for preparing the amino alcohol compounds characterized by the optically active corresponding to. Which it is useful intermediates used in the preparation of organic compounds having a number of chiral ligands and biological activity.; Formula 1; In the formula 1, Y is a hydrocarbyl Queenie pyridinyl represented by hydrochloride Queenie carbonyl or (3) represented by the formula 2, X is if 0 or X is 0, to indicate the number of carbon atoms to four unsaturated compound displays a pyridazine, X It indicates that the number of carbon atoms when the unsaturated compound 4 phthalazine and, R denotes a methoxy, ethoxy or a methyl group.