Immune responses against HPVhuman papillomavirus antigens elicited by compositions comprising an HPV antigen and a stress protein or an expression vector capable of expression of these proteins

摘要

The invention From papilloma indicated by the virus (HPV), or immune response against the HPV protein antigen exhibited by the infected cells, including cells from the cervix, and other tumors, preferably a cell-phase, in particular the cell-mediated cellular fusion It relates to a composition for inducing an immune response. In one aspect, the composition comprises an HPV protein antigen joined to the stress protein (or heat shock protein (Hsp)). The HPV protein antigen with or binding moiety by a chemical bond or may be bonded to the stress protein non-covalently, HPV protein antigen and stress protein to be coupled to a fusion protein containing both the HPV protein antigen and stress protein sequences have. In another embodiment, the composition comprises a HPV protein comprising a coding sequence encoding an antigen and a stress protein sequence, an expressible form of an expression vector. Since the expression vector can be introduced into the subject cell or transduced cell of the subject in vitro and use it, thereby HPV protein antigens that will stimulate the immune response of the subject to the HPV protein antigen-stress protein the fusion protein is expressed. The present invention also provides compositions comprising a stress protein and another component is a different pharmacologically acceptable coupled to the HPV protein antigen; -HPV stress protein antigen fusion protein and the conjugate; And to expression vectors capable of encoding a fusion protein, and instructions for its expression comprising a stress protein and HPV protein antigen sequence in a cell of the subject. The invention also HPV protein antigen, including HPV, and HPV- associated tumor-relates to the use of these compositions for inducing an immune response to the display cell.