The chemical formula of the novel polycyclic erythromycin compound and the salt thereof that is acceptable as chemical counter drug and the carrier and the combined therapeutically effective amount acceptable ester, pharmaceutically having (I), (II) or (III) to have, antibiotic activity a method by administering a pharmaceutical composition containing a compound of the invention of the composition and therapeutically effective amount comprises a compound of the present invention to a mammal to treat a bacterial infection are described.; Formula I; Formula II; Formula III
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