首页> 外国专利> -- BIODEGRADABLE LOW MOLECULAR WEIGHT TRIBLOCK POLYLACTIDE--GLYCOLIDE POLYETHYLENE GLYCOL COPOLYMERS HAVING REVERSE THERMAL GELATION PROPERTIES

-- BIODEGRADABLE LOW MOLECULAR WEIGHT TRIBLOCK POLYLACTIDE--GLYCOLIDE POLYETHYLENE GLYCOL COPOLYMERS HAVING REVERSE THERMAL GELATION PROPERTIES

机译:-生物可降解的低分子量三嵌段聚乳酸-聚乙交酯聚乙烯乙二醇共聚物具有相反的热胶凝性能

摘要

Block consisting of a large amount of hydrophobic polymer composed of poly (lactide-co-glycolide) copolymer or poly (lactide) polymer and a small amount of hydrophilic polyethylene glycol polymer B-block as A-block and having a total weight average molecular weight Soluble ABA-or BAB-triblock polymers, which exhibit reversible thermal gelation properties. Effective concentrations of triblock polymer and drug are uniformly included in the aqueous phase to form a drug delivery composition. The drug release rate can be controlled by varying the hydrophilic / hydrophobic component content, polymer concentration, molecular weight and dispersity of the triblock polymer. Since the triblock polymer is amphoteric, it is a composition as can be seen from the phase diagram showing the gelation behavior of the PLGA-PEG-PLGA triblock copolymer aqueous solution studied at different concentrations and temperatures. Thereby increasing the solubility and stability of the drug.
机译:由大量的疏水性聚合物组成的嵌段,该疏水性聚合物由聚(丙交酯-乙交酯共聚物)或聚(丙交酯)聚合物组成,以及少量的亲水性聚乙二醇聚合物B嵌段作为A嵌段,并且具有重均分子量可溶性ABA-或BAB-三嵌段聚合物,具有可逆的热胶凝性能。有效浓度的三嵌段聚合物和药物均匀地包含在水相中以形成药物递送组合物。可以通过改变三嵌段聚合物的亲水/疏水组分含量,聚合物浓度,分子量和分散度来控制药物释放速率。由于三嵌段聚合物是两性的,因此它是一种组成,从显示在不同浓度和温度下研究的PLGA-PEG-PLGA三嵌段共聚物水溶液的凝胶行为的相图可以看出。从而增加药物的溶解度和稳定性。

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