Compounds and Methods for the Treatment of Bacterial Dysentery Using Antibiotics and Toxin Binding Oligosaccharide Compositions

摘要

The present invention is pathogenic E. It relates to the treatment of diarrhea and related conditions caused by E. coli infection. More specifically, the present invention is directed to pathogenic E. coli whenever antibiotics are administered. It is based on the unexpected discovery that improved treatment is provided by administering a composition that binds and removes shiga like toxin (SLT) produced by E. coli. A novel composition containing an antibiotic and a toxin binding composition and a method of treatment using the method of simultaneously administering the toxin binding composition whenever an antibiotic is administered are provided. These compositions and methods provide for enteric E. coli to cause disease. E. coli organisms are killed and / or neutralized SLT produced by the organism and / or liberated from them when the organism dies. Thus, these compositions and methods can alleviate the symptoms of infection better than conventional treatment and can better inhibit the progression of hepatitis uremic syndrome (HUS).