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ORAL PREPARATIONS CONTAINING FORSKOLIN DERIVATIVES AND PROCESS FOR PRODUCING MEDICINAL PREPARATIONS

机译:包含佛斯考林衍生物的口服制剂以及制备药物制剂的方法

摘要

A salt of a forskolin derivative represented by the following general structural formula (1), such as colforsin dapropate hydrochloride [hydrochloride of 6-(3-dimethylaminopropionyl) forskolin] And an alkali metal halide, which are excellent in storage stability.;In the above formula, ROneRepresents hydrogen; R4Represents a vinyl group; R2And R3One of;-CO (CH2) mNR5R6(Where R5And R6And m represents an integer of 1 to 5, and the other represents hydrogen or-CO (CH2)nX where X is hydrogen or-NR7R8(Where R7And R8Each represent a lower alkyl group and the like, and n is an integer of 1 to 5].
机译:由下列通式(1)表示的福斯高林衍生物的盐,例如考尔福斯丙酸酯盐酸盐[6-(3-二甲基氨基丙酰基)福斯高林的盐酸盐]和碱金属卤化物,其储存稳定性优异。上式中,R One 代表氢; R 4 表示乙烯基; R 2 和R 3 其中之一; -CO(CH 2 )mNR 5 R 6 < / Sup>(其中R 5 和R 6 And m表示1到5的整数,另一个表示氢或-CO(CH 2 n X其中X是氢或-NR 7 R 8 (其中R 7 And R < Sup> 8 分别表示低级烷基等,n为1〜5的整数。

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