TRANSGENIC ANIMAL SHOWING VASCULAR TISSUE-SPECIFIC EXPRESSION OF ANGIOTENSIN II2 RECEPTOR

摘要

Transgenic animal and its progeny, characterized in that the angiotensin Ⅱ2 receptor expression in vascular tissue-specific; The transgenic animals and their offspring methods of production; Recombinant gene for transgenic animal containing a promoter region and Ⅱ2 angiotensin receptor gene of the protein gene derived production expressed in vascular tissue; Vascular tissue specific to the vascular tissue fragments or blood cell derived from a transgenic animal, characterized in that the angiotensin Ⅱ2 receptor expression; Method for using the transgenic animal analyze vascular physiology and / or blood pressure control action of angiotensin Ⅱ2 receptor in vivo; And a method for analyzing vascular physiological function and / or blood pressure control action of angiotensin Ⅱ2 receptor in vitro, using the vascular tissue fragments or blood cells.