CULTURED ENDOTHELIAL CELLS EXPRESSING PROTEIN WITH Iamp;B- ACTIVITY, DNA SEQUENCE ENCODING PROTEIN, RECOMBINANT DNA STRUCTURE, METHOD OF CELLS PREPARING, PROTEIN SHOWING Iamp;B- ACTIVITY

摘要

FIELD: medicine, molecular biology. SUBSTANCE: invention describes endothelial cells expressing protein with I&B-activity that results to complete repression of NF&B- -dependent activation of these cells. Cells can be obtained by change of genotype of indicated cells, for example, by insertion of heterologous sequences encoding I&B-activity or promoter. Promoter provides constructive expression of I&B- -activity being directly after effects by stimuli activating endothelial cells or if necessary as the response to the exogenous predetermined stimulus. Invention provides making transplanting material useful for transplantation, for example, for xenotransplantation since they are characterized by the favorable and less rejection probability. EFFECT: improved properties of transplanting material. 16 cl, 5 ex