N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF INHIBITION OF NEUROGENIC INFLAMMATION

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel N-substituted azaheterocyclic carboxylic acid of the formula (I) or their salts where R¹ and R² mean independently hydrogen, halogen atom, trifluoromethyl-group, C₁-C₆-alkyl or C₁-C₆-alkoxy-group; Y means groups or =CH where underlined atom takes part in cyclic system; X means groups -O-, -S-, -CR⁷R⁸-, -CH₂-CH₂-, -CH= CH--CH₂-, -CH₂-CH= CH-, -CH₂CH₂CH₂-, -CH= CH-, -NR⁹-(C=O)-, -O-CH₂-, -(C=O)- or -(S=O)- where R⁷, R⁸, R⁹ mean independently hydrogen atom or C₁-C₆-alkyl; r = 1, 2 or 3; M = 1 or 2; n = 1 when m = 1 and n = 0 when m = 2; R⁴ and R⁵ each means hydrogen atom or when m = 2 then both in common can form a bond; R⁶ is hydroxyl or C₁-C₈-alkoxy-group, or its pharmaceutically acceptable salt under condition that compounds 10-[3-(3-carbomethoxy-1-piperidyl)-propyl} -phenothiazine and 10-[3-(3-carbohexoxy-1-piperidyl)-propyl] -phenothiazine are not included. Compounds of the formula (I) inhibit neurogenic inflammation and can be used in medicine. Invention describes also method of synthesis of compounds of the formula (I), pharmaceutical composition and method of inhibition of neurogenic inflammation. EFFECT: improved method of synthesis, valuable medicinal properties. 9 cl, 2 tbl, 18 ex