DERIVATIVES OF IMIDAZOLE, METHODS OF THEIR SYNTHESIS, INTERMEDIATE SUBSTANCES AND PHARMACEUTICAL COMPOSITIONS BASED ON IMIDAZOLE DERIVATIVES

摘要

FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to derivatives of imidazole of the general formula (I) where R₁ is H, alkoxy-group, 1,3-dioxolane, dioxane, phenyl, benzoyl or phenylethyl where phenyl is substituted possibly with hydroxy-group or C₁-C₄-alkoxy-group; R₂ and R₃ are similar or different taken among halogen atom, free carboxy-radical or carboxy-radical esterified with C₁-C₄-alkyl; formyl, alkyl, phenylthio-group and alkylthio-group that are substituted possibly with one or some radicals taken among halogen atoms, hydroxy-group, C₁-C₄-alkoxy-group, free or esterified carboxy- -group and phenyl substituted possibly with hydroxy-group or C₁-C₄-alkoxy-group; Y is phenyl substituted with two radicals forming in common dioxol, one or some halogen atoms. Compounds show antagonistic properties with respect to endothelin receptors. EFFECT: improved method of synthesis, valuable pharmacological properties. 11 cl, 2 tbl, 29 ex