DERIVATIVES OF N-HETEROARYLPYRIDINESULFONEAMIDE, METHODS OF THEIR SYNTHESIS (VARIANTS), PHARMACEUTICAL COMPOSITION, METHOD OF COUNTERACTION TO ONE OR MORE EFFECTS OF ENDOTHELIN

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of N-heteroarylpyridinesulfoneamide of the general formula (I) where one of A¹ and A³ means nitrogen atom and another means CH; each of A³ and A⁴ means CH; Ar means phenyl-group that may be free or carries one substituent; W, X, Y, Z can mean nitrogen atom or CH-group; R¹ is hydrogen or halogen atom, and their pharmaceutically acceptable salts. Compounds show endothelin-receptor antagonistic activity and can be useful for treatment of patients with diseases or states where increased or anomal endothelin levels have essential causative importance. Also, invention relates to methods of synthesis of compounds and their use in medicinal therapy. EFFECT: improved method of synthesis, valuable medicinal properties of compounds. 17 cl, 71 ex