where R means the group of the formula (I') ; X means S; R1 means H, OH, OA; A means alkyl with 1-6 carbon atoms where 1-7 hydrogen atoms can be substituted with F. Compounds show properties of endothelin receptor antagonists and therefore they can be used for treatment of patients with hypertension, cardiac insufficiency, coronary heart diseases, renal, cerebral and myocardial ischemia. EFFECT: improved method of synthesis, valuable medicinal properties of compounds. 6 cl, 1 tbl, 24 ex"/>
DERIVATIVES OF 2,1,3-BENZOTHIADIAZOLE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND MEDICINAL AGENT
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DERIVATIVES OF 2,1,3-BENZOTHIADIAZOLE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND MEDICINAL AGENT
DERIVATIVES OF 2,1,3-BENZOTHIADIAZOLE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND MEDICINAL AGENT
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机译：2,1,3-苯并噻唑的衍生物，其合成方法，药物成分和药物成分
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FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of 2,1,3-benzothiadiazole of the general formula (I) where R means the group of the formula (I') ; X means S; R1 means H, OH, OA; A means alkyl with 1-6 carbon atoms where 1-7 hydrogen atoms can be substituted with F. Compounds show properties of endothelin receptor antagonists and therefore they can be used for treatment of patients with hypertension, cardiac insufficiency, coronary heart diseases, renal, cerebral and myocardial ischemia. EFFECT: improved method of synthesis, valuable medicinal properties of compounds. 6 cl, 1 tbl, 24 ex
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机译：领域：有机化学，药学。物质：发明涉及通式（I）的2,1,3-苯并噻二唑的衍生物<图像文件=“ 00000005.GIF” he =“ 22” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 35” />，其中R表示公式（I'）的组。; X表示S; R 1 表示H，OH，OA; A表示具有1-6个碳原子的烷基，其中1-7个氢原子可被F取代。化合物具有内皮素受体拮抗剂的特性，因此可用于治疗高血压，心脏功能不全，冠心病，肾病，脑和心肌缺血。效果：改进的合成方法，有价值的化合物药物特性。 6 cl，1 tbl，24前
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