METHOD FOR PREVENTING AND TREATING TRANSPLANT- HOST RESPONSE BY STIMULATING ANTI-IDIOTYPIC SUPPRESSION OF DONOR LYMPHOCYTES IN EXPERIMENTAL MODEL

摘要

FIELD: medicine. SUBSTANCE: method involves stimulating anti-idiotypic response in unirradiated mice F1(BALB/c x C57BL/6)-recipients of maternal splenocytes (C57BL/6). It is achieved by immunizing recipients with antibodies against superficial antigens of BALB/c lymphocytes as transplant-host response targets. The antibodies are produced by immunizing intermediate recipient of the third haplotype with BALB/c lymphocytes, separated on immunosorbent prepared from the lymphocytes and immobilized on dialdehydecellulose for increasing immunogenicity. EFFECT: enhanced effectiveness of treatment. 3 dwg