New indanyl-substituted benzenesulfonamide derivatives, as potassium channel blockers useful as safe antiarrhythmic agents, e.g. for treating atrial fibrillation or flutter

摘要

5-(Indan-(1 or 2)-ylaminocarbonyl)-benzenesulfonamide derivatives (I) are new. Benzenesulfonamide derivatives of formula (I) and their salts are new. R1, R2 = -CrH2r-R20 (where one CH2 of CrH2r is optionally replaced by O, CH=CH, CC, CO, COO, OCO, S, SO, SO2, N(R21) or CON(R21)); or R1 + R2 = tetra- or pentamethylene chain (in which one CH2 is optionally replaced by O, S, NH, NMe or N(CH2Ph)); R21 = H or 1-3C alkyl; R20 = H, CH3, CH2F, CFH2, CF3, C2F5, C3F7, 3-8C cycloalkyl, NR22R23, CONR22R23, OR24, COOR24, Ph' or Het; Ph' = phenyl (optionally substituted by 1 or 2 Q); Het = N-containing heterocycle containing 1-9C (optionally substituted by 1 or 2 Q); Q = halo, CF3, NO2, CN, NH2, OH, Me, Et, CH2OH, hydroxyethyl, OMe, NMe2, SO2NH2, SO2Me or NHSO2Me; R7, R10, R11, R22, R23, R26, R27, R28 = H or 1-4C alkyl; or R22 + R23, R26 + R27 = tetra- or pentamethylene chain (in which one CH2 is optionally replaced by O, S, NH, NMe or N(CH2Ph)); R24 = H or 1-3C alkyl; r = 0-8; R3-R6 = H, halo, 1-5C alkyl, 3-8C cycloalkyl, CN, CF3, NO2, OR25 or NR26R27; R25 = H, 1-4C alkyl, Ph' or -CxH2xCFyH3-y; x = 0-3; y = 1-3; R8 = a group of formulas (i) or (ii); R9 = H, OR28 or OCOR28; R12-R15 = Ph', Het, thienyl or furyl (both optionally substituted by 1 or 2 Q), H, halo, 1-5C alkyl, 3-8C cycloalkyl, CN, CF3, C2F5, C3F7, N3, NO2 or -Y-CsH2s-R29; Y = O, CO, COO, OCO, S, SO, SO2, OSO2, SO2NR24, CONR24 or NR24SO2 (all bonded to the basic structure at the left-hand terminal); s = 0-6; R29 = H, Me, CF3, C2F5, C3F7, 3-8C cycloalkyl, OR24, COOR24, NR22R23, CONR22R23, Ph' or Het. An Independent claim is included for the preparation of (I).