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Primary aliphatic or aromatic amine preparation in high yield, for use in plant protectant or pharmaceutical applications, by reductive amination of aldehyde in presence of disodium tetraborate
Primary aliphatic or aromatic amine preparation in high yield, for use in plant protectant or pharmaceutical applications, by reductive amination of aldehyde in presence of disodium tetraborate
Preparation of primary aliphatic or aromatic amines (I), by the catalytic hydrogenation of aldehydes (II) in presence of ammonia and a hydrogenation catalyst, is carried out in the additional presence of disodium tetraborate. Preparation of amines of formula R1CH2NH2 (I), by the catalytic hydrogenation of aldehydes of formula R1CHO (II) in presence of ammonia and a hydrogenation catalyst, is carried out in the additional presence of disodium tetraborate. R1 = 1-12C alkyl, 3-8C cycloalkyl, 6-12C aryl (optionally substituted by halo and/or 1-12C alkyl), 7-10C aralkyl (optionally ring-substituted by halo and/or 1-12C alkyl) or an aldose residue of formula CiH2i+1 (optionally having one H replaced by a saccharide residue); i = 2-5.
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