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AN IN VITRO ASSAY METHOD FOR THE STUDY OF BRAIN AGING
AN IN VITRO ASSAY METHOD FOR THE STUDY OF BRAIN AGING
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机译:脑老化研究的体外评估方法
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摘要
Cultured brain slices are treated with a free radical generator, in the presence of a lysosomal enzyme inhibitor (specifically an inhibitor of two cathepsins). The treated brain slices rapidly develop autofluorescent lipofuscin granules-a universal feature of brain aging. Other correlates of the aged brain are also induced by this treatment, thereby providing an in vitro model for (1) the study of brain aging; (2) assessment of anti-brain aging drugs; and (3) therapeutics directed at the clinical condition referred to as neuronal ceroid-lipofuscinosis.
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