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Preparation for topical application to the male sexual organ
Preparation for topical application to the male sexual organ
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机译:准备局部应用到男性性器官
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摘要
The preparation for topical application to the male sexual organ to overcome erectile dysfunction comprises, as active ingredients, at least one vasodilator and an aloe extract. The preparation includes adjuvants such as one or more of stearic acid, triethanolamine, silicone oil, cetyl alcohol, glycerol, acidic carboxyvinyl gelling agents, methyl cellulose, wax emulsifiers, methyl paraben and propyl paraben so as to form an aqueous cream or gel. The aloe extract is preferably prepared using an extract prepared from the plant aloe ferox which contains at least 30 per cent by weight amino acids and also includes polysaccharides. The vasodilator may comprise glyceryl trinitrate and/or isosorbide dinitrate, or combination of theophylline and ethylene diamine, or co-dergocrine mesylate (ie a combination of dihydroergocornine mesylate and dihydroergocristine mesylate with alpha- and beta- dihydroergocryptine mesylate). To assist penetration the adjuvants may include one or more of propylene glycol, isopropyl palmitate and isopropyl myristate. Preferably the preparation is substantially thixotropic and supplied in unit dosage form. The preparation is preferably manufactured by mixing the active ingredients as a finely divided solid or as a solution to form a solution or dispersion in an aqueous cream or gel composition. The aloe extract and one or more gelling agents are advantageously prepared as one batch, a soap composition is prepared as a second batch and thereafter the two batches are mixed to form a homogeneous mixture to which the vasodilator is admixed.
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