Substrates for assessing mannan-binding protein-associated serine protease activity and methods using the substrates

摘要

Provided herein are assays for measuring in vivo levels of activated mannan-binding protein-associated serine protease (MASP-1 and MASP-2) activity. Also provided are compounds that are useful for assessing the in vivo levels and for monitoring in vitro and in vivo complement-activation (C-activation).