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Antisense oligonucleotide compositions targeted to angiotensin converting enzyme MRNA and methods of use
Antisense oligonucleotide compositions targeted to angiotensin converting enzyme MRNA and methods of use
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机译:靶向血管紧张素转化酶MRNA的反义寡核苷酸组合物及其使用方法
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摘要
Antisense oligonucleotides specific for mammalian ACE mRNA have been identified. Administration of these oligonucleotides to animals resulted in a decrease in blood pressure, but no significant change in heart rate. Methods for discovering other oligonucleotides with the same activity are taught, as are uses of the antisense molecules for treatment of human and animal diseases.
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